Professor of Radiology in Radiation Oncology & Neuroscience
Endowed Professor of Imaging Research in Radiology
Director, Molecular Imaging Innovations Institute
Director, Perioperative Imaging & Engineered Technologies
Head, Cross-Campus Research Collaborations & Innovations
Cornell Engineering Innovations in Medicine
Sandra and Edward Meyer Cancer Center
Weill Cornell Medical College
AREAS OF SPECIALIZATION: Nanomedicine/ Engineered Particle- and Cellular Immunotherapies/ Targeted radiotherapies/ /Tumor microenvironment / Microscopy / Multimodal Molecular Imaging
TECHNOLOGY DEVELOPMENT: Fluorescence-guided anatomic and functional imaging and therapeutics; Super-resolution microscopy – spectral multiplexing, multimodal imaging tools for assessing functional parameters and biomarkers.
DIAGNOSTIC/THERAPEUTIC PROBE DEVELOPMENTS:
Dual Modality / Optical Imaging
C’ do (ultrasmall core-shell silica nanoparticles)
cRGD-PEG-Cy5-C’ dots – integrin-targeted optical detection, lymph nodes (Clinical Trial: P1, P2)
89Zr-DFO-cRGDY-Cy5-C’ dots – PET detection, metastatic nodes (Clinical Trial: P1)
PSMAi-PEG2-Cy5 (or Cy5.5)-C’ dots – imaging / modulation, TME
89ZrDFO-PSMAi-Cy5 (or Cy5.5)-C’ dots – PET detection, metastatic nodes, margins (Clinical Trial: P1)
GRP-cw800-C’ dots –(gastrin-releasing peptide) imaging / modulation, TME
89Zr-DFO-GRP-Cy5.5-C’ dots – PET imaging detection of metastatic nodes, margins
aMSH-Cy5-C’ dots – (alpha melanocyte stimulating hormone peptide) imaging
89Zr-DFO-aMSH -Cy5-C’ dots – PET imaging detection of metastatic nodes, margins
Therapeutic Platforms
Cellular Immunotherapies and Antibody Fragments
Targeted Immunomodulatory C’ dots
Targeted Radiotherapies
Drug Delivery
DEVICE CO-DEVELOPMENTS:
Fluorescence-guided surgical camera systems for multiplexing and functional imaging, Super-resolution microscopy with spectral multiplexing capabilities
APPLICATIONS: Oncology, Inflammatory Diseases, Neurodegenerative disorders
GRANTS:
R01CA243085 (NCI)
R01CA253658 (NCI)
PC220534 (DOD)